补肾清热法联合替卡韦治疗慢性乙型肝炎(alt≤2#215;uln)肝损伤研究.pdfVIP

The Research of Liver Injury of the Method of Bushenqingre with Entecavir in Treating Chronic Hepatitis B （ALT ≤2 ×ULN ） Speciality:Internal medicine of TCM. Author:Sun Peng Fei . Tutor:Professor Li Yong. Abstract Objective: To explore the clinical effect of the method of Bushenqingre with entecavir in treating chronic hepatitis B （ALT ≤2 ×ULN ）. Methods: 42 cases of chronic viral hepatitis patients （ALT ≤2 ×ULN ）( which before and after treatment of liver biopsy in 21 cases ) were randomly choosed , giving the civet party particles, 1 agent daily; entecavir 0.5mg / d, 48 weeks treatment. To observed before and after treatment in hepatic tissue pathology and related indexes of liver function. Results: after treatment of 48 weeks, patients whatever in HBeAg ( + ) or ( - ) can effectively appear virologic response, the levels of ALT and AST were significantly decreased than before treatment ( P 0.01); two groups of patients with histological improvement were not ideal, statistical analysis revealed no differences ( P 0.05). Conclusion: the method of Bushenqingre with entecavir play significantly effective in suppressing viral replication, improving liver function; but because the liver parenchyma of slow recovery and other reasons, unable to significantly improve liver pathology. Key words method of Bushenqingre ;entecavir; chronic hepatitis B; liver injury 目 录 引 言 1 资料与方法 2 一、病例资料 2 （一）诊断标准 2 （二）纳入标准 2 （三）排除标准 2 （四）病例剔除及脱落标准 2 二、肝组织穿刺活检资料 3 （一）肝组织穿刺活检禁忌证 3 （三）器械准备 3 （四）操作步骤 3 （五）术后处理 4 （六）判断标准 4 三、一般资料 4 （一）病例来源 4 （二）一般情况 4 四、研究方法 6 （一）药物及治疗方法 6 （二）检测指标 6 （三）