W肿瘤免疫学.ppt

How In the spleen, the highest uptake of siCCR2 was by LY6Chi monocytes. Treatment with siCCR2 resulted in decreased CCR2 expression on splenic LY6Chi monocytes, and these cells did not migrate towards CCL2. What siCCR2 treatment: tumour growth ↓ TAM ↓ VEGF↓ microvessels in the tumour ↓ Conclusion Therapeutic siRNA-mediated silencing is a potential strategy for treating inflammatory diseases 与抗肿瘤化疗药物相关的转基因治疗 肿瘤药物增敏基因治疗 肿瘤耐药基因治疗 肿瘤药物敏感基因治疗 增敏基因 如将钙调素基因转入癌细胞，可提高癌细胞对长春新碱通透性 耐药基因 MDR（多药耐受基因）、DHFR（二氢叶酸脱氢酶）基因，可增强骨髓细胞对抗瘤药物耐受性 将耐药基因导入造血干细胞，可保护正常干细胞在大剂量化疗时免受药物损伤。 Thanks for yo