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W抗原与抗原递呈要点.ppt
Cross-presentation 交叉递呈 First extensively documented in the mid-1970s in studies by Bevan. ▲Bevan, M.J. Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay. J. Exp. Med. 143, 1283–1288 (1976). ▲ Bevan, M.J. Minor H antigens introduced on H-2 different stimulating cells crossreact at the cytotoxic T cell level during in vivo priming. J. Immunol. 117, 2233–2238 (1976). Two models of cross-presentation Peter Cresswell . Nat Immunol. 2004 What else ? Has anyone left ? I am here ! We are peptides. So pity! Why not us ? Presentation of Nonpeptide Antigens The class I–like(CD1) molecules NKT cells A specialized subset of T cells: coexpression of NK1.1, and an invariant Va?14/Ja?281 TCRa?-chain coupled with V?8.2, 7 or 2 TCR-? chains. Specifically recognizes glycolipid-Ag in conjunction with the MHC class I–like molecule, CD1d. Disruption of either the invariant TCR-a chain, or CD1d, results in a selective deficiency of NK T cells. Upon TCR stimulation, NK T cells rapidly produce both Th1 (e.g. IFN-g? and TNF-a?) and Th2 cytokines (e.g. IL-4, IL-10, IL-13). NKT cells NKT cell defects and disease S. P. Berzins (2011) Nat. Rev. Immunol. Models for the development of NKT cells Annu. Rev. Immunol. 2005. 26:877–900 Models for the development of NKT cells Annu. Rev. Immunol. 2005. 26:877–900 Nat.Rev. Immunol. 2:557 J.Banchereau, F. Briere, Ch. Caux,J. Davoust et al.Immunobiology of dendritic cells. Annu.Rev. Immunol. 2000, 18: 767-811. Itano AA, Jenkins MK.Antigen presentation to naive CD4 T cells in the lymph node.Nat Immunol. 2003;4(8):733-9. Anne L Ackerman Peter Cresswell.Cellular mechanisms governing cross-presentation of exogenous antigens. Nat Immunol. 2004; 5(7):678-684 Geroge D.Snell. Studies in histocopatibility. Nobel lecture.1980:645 Further Reading * * Antigen recognition by TC cells exhibits MHC restriction * Selected MHC Class I
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