CAST研究PPT课件.pptVIP

CAST: Cardiac Arrhythmia Suppression Trial Purpose To determine whether therapy with class Ic antiarrhythmics to suppress asymptomatic or mildly symptomatic ventricular arrhythmias after MI reduces mortality due to arrhythmia Reference The CAST Investigators. Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. N Engl J Med 1989;321:406–12. CAST: Cardiac Arrhythmia Suppression Trial - TRIAL DESIGN -  Design Multicenter, multinational; initial phase open; main phase randomized, double