COPERNICUS研究PPT课件.pptVIP

COPERNICUS: Carvedilol Prospective Randomized Cumulative Survival trial Purpose To assess the effect of carvedilol, a β1-, β2- and α1-receptor blocker, on mortality in patients with severe chronic heart failure Reference Packer M, Coats AJS, Fowler M et al. for the COPERNICUS Study Group. Effect of carvedilol on survival in severe chronic heart failure. N Engl J Med 2001;344:1651–8. COPERNICUS: Carvedilol Prospective Randomized Cumulative Survival trial- TRIAL DESIGN - Design Multicenter, multinational, randomized, double-blind, placebo-controlled Patients 2289 patients wi