RALES研究PPT课件.pptVIP

RALES: Randomized Aldactone Evaluation Study Purpose To determine whether the aldosterone antagonist spironolactone reduces mortality in patients with severe heart failure Reference Pitt B, Zannad F, Remme WJ et al. for the Randomized Aldactone Evaluation Study Investigators. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 1999; 341: 709–17. RALES: Randomized Aldactone Evaluation Study- TRIAL DESIGN - Design Multicenter, multinational, randomized, double-blind, placebo-controlled Patients 1663 patients in NYHA class