奥硝唑衍生物的合成_样稿.docVIP

湖南化工职业技术学院 毕??业??论??文 题 目: 　奥硝唑衍生物的合成 院系名称: 　制药与生物工程系 专业班级: 　化学制药1211 学生姓名: 　　　 学 号: 　 　 指导老师: 　 吴 超 2014年 10 月 30 日  摘 要 硝基咪唑类化合物是由咪唑在浓硫酸中硝化得到的，其中大多数都是重要的医药中间体。硝基咪唑类药物起初是作为抗滴虫及阿米巴原虫药应用于临床的，后来研究发现其具有较好的抗厌氧菌作用，并在临床上得到了广泛的应用。 二茂铁及其衍生物以其独特的化学结构和由此所具有的特殊的物理、化学性质而迅速地占据了有机金属化学领域的前沿，并成为现代化学的重要研究课题之一。 由于二茂铁的特殊结构使其不仅具有芳香性、亲脂性、稳定性、低毒性及氧化还原的可逆性，而且，分子中所含铁原子还可以作为提供生物体内铁元素的来源。 因此, 二茂铁衍生物的生物和生理活性的研究受到了科学家们的极大关注，如抗肿瘤、抗贫血、杀菌、杀虫、抗炎和抗疟疾等，它已成为金属有机化学的热门领域之一。本论文的主要研究了新型奥硝唑二茂铁衍生物的合成方法。 关键词： 硝基咪唑；奥硝唑；二茂铁；酯化反应  Title Synthesis of Ornidazole derivatives Abstract The compounds of nitro-imidazole derivatives are prepared by nitrating imidazole in sulphuric acid, and most of them are important pharmaceutical intermediates. Ornidazole was derived from nitro-imidazole and applied in killing infusorian and amebic protozoa clinically, later,, in was discovered that it can kill anaerobe, and applied widely. In recent years, the discovery of ferrocene and elucidation of its remarkable structure is arguably the starting point for modern organometallic chemistry. Recently, increasing interests have been focused on developing structural variations of established drugs by metallocenic organometallic compounds as alternatives of the chemotherapy of drug-resistance in cancer and tropical diseases. The stability, non-toxicity and readily membrane-permeation of the ferrocenyl group, the accessibility of a large variety of derivatives, as well as its favourable electrochemical properties have made ferrocene and its derivatives very suitable for biological applications and for conjugation with biomolecules. Accordingly, using ferrocenyl-containing derivatives as medicines and other chemotherapeutants has long been recognized as an attractive way. This article will use atomic fluorescence spectrophotometric determination of industrial water in