含氮杂环铂(Ⅳ)配合物的合成、表征介绍.doc

含氮杂环铂（Ⅳ）配合物的合成、表征 及抑菌性能研究 李清萍 张琼 缐萍 宋玉民( （西北师范大学化学化工学院 甘肃 兰州 730070） 摘 要 本文利用溶剂热法和水热法，分别以咪唑(imidazole)、2,2′-联咪唑(2,2′-biimidazole)和邻菲咯啉(phenanthroline)为配体在乙醇水溶液中与氯铂酸钾作用合成了三种铂（Ⅳ）二元配合物。结合红外光谱(IR)、元素分析、差热-热重分析(TG-DTA)以及紫外可见光谱UV-Vis)确定其化学组成分别为Pt(Im)2Cl4·H2O(Ⅰ)，PtH2biimCl4·H2OPtPhenCl4·H2O(Ⅲ)。同时研究了三种配合物对大肠杆菌、金黄色葡萄球菌和枯草芽孢杆菌的抑菌性，结果表明配合物(Ⅰ)和(Ⅱ)配合物(Ⅲ)的抑菌活性与其配体的抑菌活性没明显差别，这可能是配合物结构及细菌细胞特性共同影响的结果；同时还发现三种配合物对大肠杆菌的抑制活性略高于其他两种菌类。最后，对所得配合物的抑菌机理进行了探讨。 关键词 铂配合物；含氮杂环化合物；牛津杯法；抑菌性质 Synthesis，Characterization and Antimicrobial Study of Platium（Ⅳ）Complexes with Compounds Containing N Group(aCollege of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070) Abstract The complexes of Pt(Im)2Cl4·H2O(Ⅰ), PtH2biimCl4·H2O (Ⅱ) and Pt(Phen)Cl4·H2O (Ⅲ), were synthesized by the reaction of potassium platinum(Ⅳ) chloride with corresponding ligands in ethanol aqueous solution by solvent-thermal and hydrothermal method,. The composition of complexes ,which were confirmed to be Pt(Im)2Cl4·H2O(Ⅰ), PtH2biimCl4·H2O (Ⅱ) and Pt(Phen)Cl4·H2O (Ⅲ), respectively, was characterized by IR, elemental analysis, thermogravimetric analysis and UV-Vis spectrum. The antibacterial activity of the complexes against B.Subtitis、E.Coli and Staphyloccocus aureus was also studied,which indicated that the complexes Pt(Im)2Cl4·H2O and PtH2biimCl4·H2O had better antibacterial effect on the testing bacterium than the corresponding ligand, imidazo and 2,2′-biimidazole, respectively. Due to the combined effect of complex structure and the characteristics of bacteria cells, the antibacterial activity of PtPhenCl4·H2O has no significant difference with that of phenanthroline. The three complexes all have the best inhibitory effect on E. coli during three kinds of bacteria mentioned above. We also further investgated their antibacterial mechism. Finally, the antibacterial mechanism of the complexes obtained was discussed. Key words Platiumn（）igands Containing N Group; Oxford plate; Antimicrobial propertie