异常黑胆质型肝癌病证模型肝脏形态学研究.pdfVIP

科技导报2014，32（14） 异常黑胆质型肝癌病证模型肝脏形态学异常黑胆质型肝癌病证模型肝脏形态学 研究研究 1 2 1 1 2 王延蛟 ，哈木拉提·吾甫尔 ，依马木·买买提依明 ，热斯拉特·艾力木 ，阿尤甫江·阿布都热依木 ， 斯坎德尔·白克力1 1.新疆医科大学基础医学院，乌鲁木齐830011 2.新疆医科大学药学院，乌鲁木齐830011 摘要摘要 为探讨异常黑胆质体液对异常黑胆质型肝癌病证模型的影响，在异常黑胆质载体大鼠模型基础上用二乙基亚硝胺（DEN） 诱导建立维吾尔医异常黑胆质型肝癌病证模型大鼠，并对大鼠第11、15、20周时肝脏的外观、病理变化等进行动态观察。20周 后，异常黑胆质病证模型组和模型对照组均发生癌变，前者成癌率（100%）明显高于后者（72%）（P0.01）。总之，在异常黑胆质 载体大鼠模型的基础上，用DEN诱导的异常黑胆质型肝癌病证模型肝癌的发生过程中，异常黑胆质体液具有促进和加快肝脏病 变的作用。本研究成功建立了异常黑胆质并DEN诱导的肝癌病证大鼠模型。 关键词关键词 维吾尔医；异常黑胆质；二乙基亚硝胺；肝癌 中图分类号中图分类号 R256.4 文献标志码文献标志码 A doidoi 10.3981/j.issn.1000-7857.2014.14.012 ARatModelofHepatocarcinomaCarryingAbnormalSavdaand ItsMorphologicalStudy 1 2 1 1 2 WANG Yanjiao, UPUR Halmurat, MAMATIMIN Imam, HELIM Resalat, ABDURIYIM Ayupjan, BAKRIIskandar1 1.CollegeofBasicMedicine,XinjiangMedicalUniversity,Urumqi 830011,China 2.CollegeofPharmacy,XinjiangMedicalUniversity,Urumqi 830011,China AbstractAbstract The effect of abnormal savda on the initiation and development of hepatocarcinoma was studied by establishing a rat model of hepatocarcinoma carrying abnormal savda. A rat model with abnormal savda disease was first established, and diethylnirtosamine(DEN)wasusedtofurtherestablishamodelofhepatocarcinomacarryingabnormalsavdaunderUighurmedicine treatment.Themorphologyandpathologicalchangesoftheliverwereobservedatthe 11th, 15thand 20thweek.Afterthe 20thweek, cancerization was induced both in the experimental group (hepatocarcinoma with abnormal savda) and the model control group (withoutabnormalsavdasyndromebutDENtreatment),butthepathologicalchangesoftheliversurfaceintheexperimentalgroup appeared faster than those in the model control group, and the incidence of hepatocellular carcinoma (1