远红外在生物医学临床上的应用及其作用机制.pdfVIP

科技导报2014，32（30） 远红外在生物医学临床上的应用及其远红外在生物医学临床上的应用及其 作用机制作用机制 1 2 1 王阳 ，水珊珊 ，王霞 1.合肥工业大学医学工程学院，合肥 230009 2.合肥工业大学生物与食品工程学院，合肥 230009 摘要摘要 远红外是一种具有强热作用的放射线。作为物理治疗的一种，远红外用于辅助治疗心血管疾病、糖尿病、慢性肾病等多种 疾病，表现出良好的临床效果，但是其作用的分子机制尚不清楚。本文从分子信号通路视角，分析远红外与细胞周期、细胞自身 保护、第二信使和后转录调控因子等的关系，提出远红外治疗诸多疾病的可能的分子机制，并总结了近年来远红外在生物医学临 床中的应用。 关键词关键词 物理治疗；远红外；分子信号通路 中图分类号中图分类号 R332 文献标志码文献标志码 A doidoi 10.3981/j.issn.1000-7857.2014.30.014 Molecular Mechanism of Far-infrared Therapy and Its ApplicationsinBiomedicine WANGYang,SHUIShanshan,WANGXia1 2 1 1.SchoolofMedicalEngineering,HefeiUniversityofTechnology,Hefei 230009,China 2.SchoolofBiotechnologyandFoodEngineering,HefeiUniversityofTechnology,Hefei 230009,China AbstractAbstract Physical therapy is an integrating domain of medicine resorts to physical modalities for the work-up, diagnosis, and treatmentofdisordersanddefects.Asarepresentativephysicaltherapy,far-infraredradiation(FIR),aninvisibleelectromagnetic wavewithwavelengthranges 3-1000 μm,hasbeenanadjuvanttreatmentforvariousdiseaseswithgoodclinicaleffects,including cardiovascular disease, diabetes mellitus, chronic kidney disease; however, the molecular mechanism through which FIR works remainselusive.Inthepresentstudy,bysystematicliteraturereviewandtextmining,weanalyzedtheeffectsofFIRonsignaling transductionnetworksincludingcellcycle,cellularself-defense,secondmessagesandpost-transcriptionalregulators.Theresults showedthatthepossiblemechanismsofFIRtherapywerecloselyassociatedwiththeinhibitionofgrowth,invasionandmetastasisof cancercells,increasednitricoxideproductionandmodulationoftheexpressionprofilesofsomecirculatingmiRNAsandheatshock proteins, and through which, it may be a beneficial compliment to some chronic diseases without any side effects. Finally, we summarizedtheapplicationofFIRtherapyinthefieldofbiomedicine. KeywordsKeywords physicaltherapy;far-infraredradiation;molecularsignalin