10.13,激素依赖性皮炎139例疗效观察.docVIP

激素依赖性皮炎139例疗效观察 陈宗劼1 农祥2 （1.丽江市人民医院 皮肤科 6741002.昆明医科大第一附属医院 皮肤科） 摘要：目的 观察他克莫司软膏治疗脸部激素依赖性皮炎的临床效果。方法 选取2012年6月-2013年12月于我院接受治疗的139例面部激素依赖性皮炎患者作为研究对象，随机将其分为对照组（n=60）与观察组（n=79）两组，对照组给予维生素E霜治疗，观察组则给予他克莫司软膏治疗，坚持治疗4周，对比两组患者的治疗效果。结果 ①观察组痊愈25例，显效31例，好转14例，总有效率高达88.6%，明显高于对照组的63.4%，组间对比差异显著（P＜0.05）；②观察组客观症状评分下降至（5.7±1.1）分，主观症状积分下降至（4.7±1.0）分，均明显低于对照组（P＜0.05）。结论 在激素依赖性皮炎患者的治疗中，采用他克莫司软膏方案，可有效降低患者的主客观症状积分，强化面部屏障功能，值得推广。 关键词：激素依赖性皮炎；他克莫司软膏；维生素E酸；效果 Hormone dependent dermatitis curative effect observation of 139 cases Abstract: Objective To observe clinical effects of tacrolimus ointment in the treatment of facial hormone dependent dermatitis. Methods 139 cases of facial hormone in 2012 June -2013 year in December in our hospital treated dependent dermatitis patients as research object, randomly divided into control group (n=60) and observation group (n=79) of two groups, the control group were given vitamin E cream treatment, the observation group were treated with tacrolimus ointment treatment, adherence to treatment for 4 weeks, compared two groups of patients with treatment effect. Results 25 cases were cured, 31 cases markedly effective, 14 cases improved, the total effective rate up to 88.6%, significantly higher than that in the control group 63.4%, contrast group differences significantly (P 0.05); the observation group objective symptom scores decreased to (5.7 + 1.1), subjective symptom integral down to (4.7 + 1), were significantly lower than the control group (P 0.05). Conclusion in the treatment of patients with hormone dependent dermatitis with tacrolimus ointment in the scheme can effectively reduce the patient subjective symptom scores, strengthen facial barrier function, worthy of promotion. Keywords: Hormone dependence dermatitis; tacrolimus ointment; vitamin E acid; effect 他克莫司软膏属于新型非激素抗炎药物的范畴，有效避免了患者对激素的依赖性，目前在面部激素依赖性皮炎患者的治疗中已有初步应用，有大量研究均提示其疗效显著[1-2]。基于此，为进一步评估他克莫司软膏治疗面部激素依赖性皮炎患者的效果，我院对近年来收治的139例患者进行了对比研究，现报告如下。 1资料与方法 1.1 一般资料 选取2012年6月-2013年12月于我院接受治疗的13