肝脂灵颗粒治疗酒精性脂肪肝(痰瘀互结型)的临床研析.docVIP

摘  要  目的：通过观察肝脂灵颗粒对酒精性脂肪肝临床症状的改善，肝功能的变化、血 脂水平的变化，肾功能的变化，肝脏影象学改变，评价肝脂灵颗粒治疗酒精性脂肪肝 的有效性及安全性。 方法：将 60 例痰瘀互结型的酒精性脂肪肝患者，随机分为空白组 20 例、治疗组 20 例、西药组 20 例。治疗前三组的性别 、年龄 、病程、饮酒史上两两之间具有可 比性（P＞0.05）。空白组给予基础治疗，不给予药物治疗；治疗组口服肝脂灵颗粒（由 大黄、水蛭、汉防己、炙甘草等组成一次 10g，每日 3 次），西药组服用多烯磷脂酰 胆碱胶囊一次 2 粒，每日 3 次；三个月为一疗程。三组患者服药前后检测肝功能（ALT、 AST）、血脂、肾功能、腹部 CT，并观察临床症状的改善情况。 结果：治疗组与西药组比较，在临床症状的改善、血清学指标恢复，影像学的改 善上，两组各项指标无显著性差异（P＞0.05）；治疗组与空白组比较，在临床症状的 改善、血清学指标恢复，影像学的改善上，各项指标比较有显著性差异（P0.05）； 西药组与空白组比较，在临床症状的改善、血清学指标恢复，影像学的改善上，各项 指标比较有显著性差异（P＜0.05）。 结论：肝脂灵颗粒可以显著的改善酒精性脂肪肝的临床症状，效果与多烯磷脂酰 胆碱胶囊相当；肝脂灵颗粒可以改善肝功能，降低血脂；肝脂灵颗粒可以改善酒精性 脂肪肝患者的影像学变化。扩大临床观察病例，下一步进行实验研究，可开发治疗酒 精性脂肪肝新药，给患者带来福音。 关键词 酒精性脂肪肝；痰瘀互结型；肝脂灵颗粒；临床研究 Clinical Research of Cure Alcoholic Fatty Liver Using Ganzhiling Granule Abstract Objective: In order to study the clinical curative effect of Ganzhiling on Alcoholic fatty liver combined with sputum silt, evaluate the influence on the liver function, blood fat, image and clinical symptoms. Estimate the efficiency and security of cure about alcoholic fatty liver. Discover one Chinese materia medica preparation which is safety and dependable on the cure of alcoholic fatty liver. Methods: Sixty one patients are randomly divided into three groups, groups of matched group, treated group and western medicine group separately has 20, 20 and 20 cases. One case in matched group was got out because of drinking during cure. General information about gender, age, course of disease and drinking histories reveals that three groups between each have comparability before cure (P＞0.05). Patients in matched group per os Ganzhiling pellet (composed with Rheum officinale, leeches, Stephania tetrandra, Radix Glycyrrhizae Preparata etc. three times a day, 10g each time). Patients in treatment group per os Ganzhiling pellet (composed with Rheum officinale, leeches, Stephania tetrandra, Radix Glycyrrhizae Preparata etc. three times a day, 10g each time). Patients in Western medicine group take Polyene Phosphatidyl Choline, three t