2014年药物研发最热门靶点逐个述评教程分析.docxVIP

目录  TOC \o 1-3 \h \z \u  HYPERLINK \l _Toc400635123 1.癌症  PAGEREF _Toc400635123 \h 2  HYPERLINK \l _Toc400635124 1.1.Bcr-Abl抑制剂  PAGEREF _Toc400635124 \h 3  HYPERLINK \l _Toc400635125 1.2.VEGF/VEGFRs抑制剂  PAGEREF _Toc400635125 \h 3  HYPERLINK \l _Toc400635126 1.3.PDGF/PDGFRs抑制剂  PAGEREF _Toc400635126 \h 3  HYPERLINK \l _Toc400635127 1.4.FGF/FGFRs抑制剂  PAGEREF _Toc400635127 \h 4  HYPERLINK \l _Toc400635128 1.5.EGFR/HER2/HER3抑制剂  PAGEREF _Toc400635128 \h 4  HYPERLINK \l _Toc400635129 1.6.HGF/c-Met抑制剂  PAGEREF _Toc400635129 \h 5  HYPERLINK \l _Toc400635130 1.7.ALK抑制剂  PAGEREF _Toc400635130 \h 7  HYPERLINK \l _Toc400635131 1.8.Aurora激酶抑制剂  PAGEREF _Toc400635131 \h 7  HYPERLINK \l _Toc400635132 1.9.CDK抑制剂  PAGEREF _Toc400635132 \h 8  HYPERLINK \l _Toc400635133 1.10.ChK抑制剂  PAGEREF _Toc400635133 \h 8  HYPERLINK \l _Toc400635134 1.11.PARP抑制剂  PAGEREF _Toc400635134 \h 9  HYPERLINK \l _Toc400635135 1.12.Bcl-2抑制剂  PAGEREF _Toc400635135 \h 9  HYPERLINK \l _Toc400635136 1.13.Hedgehog抑制剂  PAGEREF _Toc400635136 \h 10  HYPERLINK \l _Toc400635137 1.14.p53/MDM2 抑制剂  PAGEREF _Toc400635137 \h 10  HYPERLINK \l _Toc400635138 1.15.PI3K/Akt/mTOR抑制剂  PAGEREF _Toc400635138 \h 11  HYPERLINK \l _Toc400635139 1.16.Raf/MEK/ERK抑制剂  PAGEREF _Toc400635139 \h 13  HYPERLINK \l _Toc400635140 1.17.HDAC 抑制剂  PAGEREF _Toc400635140 \h 13  HYPERLINK \l _Toc400635141 1.18.免疫检查点调节剂  PAGEREF _Toc400635141 \h 14  HYPERLINK \l _Toc400635142 2.自身免疫疾病  PAGEREF _Toc400635142 \h 15  HYPERLINK \l _Toc400635143 2.1.白介素及其受体抑制剂  PAGEREF _Toc400635143 \h 15  HYPERLINK \l _Toc400635144 2.2.JAK抑制剂  PAGEREF _Toc400635144 \h 16  HYPERLINK \l _Toc400635145 2.3.p38 MAPK抑制剂  PAGEREF _Toc400635145 \h 17  HYPERLINK \l _Toc400635146 2.4.Syk抑制剂  PAGEREF _Toc400635146 \h 17  HYPERLINK \l _Toc400635147 2.5.TGFβ/Smad调节剂  PAGEREF _Toc400635147 \h 18  HYPERLINK \l _Toc400635148 3.心血管