复方七芍降压片对SHR内皮损伤的干预作用.docVIP

复方七芍降压片对SHR内皮损伤的干预作用 　　【摘要】 目的：观察复方七芍降压片对自发性高血压大鼠（SHR）的降压作用及其对血清IL-6、IL-8和TNF-α的影响。方法：以12只8周龄Wistar―kyoto（WKY）大鼠为正常组（WKY组），48只8周龄SHR随机分为4组，即模型组（SHR-M组）、卡托普利组（SHR-K组）、复方七芍降压片低剂量治疗组（SHR-D组）、复方七芍降压片高剂量治疗组（SHR-G组）。连续灌胃4周，观察比较各组血压及血清中IL-6、IL-8和TNF-α变化。结果：SHR-K组血压从第1周开始，SHR-D组血压从第3周开始，SHR-G组血压从第2周开始均低于治疗前及SHR-M组，比较差异均有统计学意义（P中国论文网 /6/view-7246031.htm 　　【关键词】 复方七芍降压片； 自发性高血压大鼠； IL-6； IL-8； TNF-α 　　【Abstract】 Objective：To explore the effect of Compound Qishaojiangya tablet on blood pressure and IL-6，IL-8，TNF-α in rats with spontaneously hypertension.Method：Twelve 8-week-old Wistar-kyoto（WKY） rats were selected as the normal group，forty-eight 8-week-old spontaneously hypertension rats （SHR） were selected and divided into 4 groups randomly，with each group 12 rates.The 4 groups were the model group（group SHR-M），the Captopril group（group SHR-K），the Compound Qishaojiangya tablet low-dose group（group SHR-D） and the Compound Qishaojiangya tablet high-dose group（group SHR-G）.Continuous lavage was given to the rates for 4 weeks.The blood pressure and the 1evels of serum IL-6，IL-8 and TNF-α in different groups were measured and compared.Result：The blood pressure of group SHR-K（1，2，3 and 4 weeks after treatment），group SHR-D（3 and 4 weeks after treatment） and group SHR-G（2，3 and 4 weeks after treatment） were all lower than before treatment and that of group SHR-M，the differences were all statistically significant（P 　　【Key words】 Compound Qishaojiangya tablet； Spontaneously hypertensive rats； IL-6； IL-8； TNF-α 　　First-authors address：The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine，Changsha 410007，China 　　doi：10.3969/j.issn.1674-4985.2015.31.004 　　高血压病患病率居慢性病首位，同时也是心脑血管病最主要的危险因素。高血压的发病机制目前尚未完全阐明，仍在不断探索中。近年来研究表明，免疫炎症反应诱导的内皮功能障碍是高血压病重要的发病机制和关键环节[1]。这提示抗炎和内皮保护等联合治疗可能成为除降压治疗之外治疗高血压病的必要手段。本实验通过观察自发性高血压大鼠（spontaneously hypertensive rats，SHR）血压、血清白细胞介素-6（IL-6）和白细胞介素-8（IL-8）及肿瘤坏死因子-α（TNF-α）中药干预后的变化，研究复方七芍降压片对高血压病降压作用的可能机制，以期在中医药方面寻求防治高血压病的新思路和新方法，现报道如下。