棘白菌素与近平滑.pptVIP

研究结果--- 不同种属念珠菌比例 10.5年间最常见的前五位念珠菌依次为：白念、光滑、热带、近平滑、 克柔念珠菌； 白念珠菌比例呈下降趋势；非白念（光滑、热带、近平滑）比例呈上升 趋势； CLSI新折点对评价抗真菌药物对念珠菌的药敏活性的影响 棘白菌素和唑类对白念、热带念珠菌的CLSI折点值降低，增加了剂量依赖或耐药的菌株数。 棘白菌素类药物对近平滑念珠菌的CLSI折点相对升高，减少了近平滑念珠菌对棘白菌素类药物耐药的数量。 The end * Recently published comparative MIC distributions for all 3 echinocandins against over 5000 clinical Candida isolates. You can see that the current breakpoint (in red) encompasses over 99% of all isolates. However, each drug has a bimodal distribution that is extremely species associated…..of the top 5 species, all but one are encompassed within 0.12-0.25 mcg/ml,