血必净注射液对重症肺炎患者炎症因子的影响.doc

血必净注射液对重症肺炎患者炎症因子的影响 　　[摘要] 目的 研究血必净注射液对重症肺炎患者炎症因子的影响。方法 随机抽取2014年3月―2015年2月该院收治于ICU的重症肺炎患者60例，随机均分成观察组（n=30）和对照组（n=30），均给予常规抗感染及营养支持、加强痰液引流、免疫调节、机械通气等对症支持治疗，观察组在此基础上加用血必净注射液抗炎治疗（50 mL，q12 h）。两组患者持续给药2周后对比疗效及炎症因子相关指标变化情况。 结果 观察组治疗后总有效率90.0%显著高于对照组63.3%，差异有统计学意义（P0.05）；治疗后观察组患者血清IL-1（118.67±9.01）pg/L、IL-6（79.68±14.82）pg/L、TNF-α（13.68±5.41）mg/L与治疗前比较明显降低，与对照组比较下降水平显著，差异均有统计学意义（P中国论文网 /6/view-7159693.htm 　　[关键词] 血必净；重症肺炎；炎症因子 　　[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2015）10（a）-0123-03 　　Effect of Xuebijing Injection on Inflammatory Factor of pPatients with Severe Pneumonia 　　QIU Shi 　　ICU of Henan People’s Hospital， Zhengzhou， Henan Province， 450003 China 　　[Abstract] Objective To study the effect of Xuebijing injection on inflammatory factor of patients with severe pneumonia. Methods 60 patients with severe pneumonia admitted into ICU of the hospital from March 2014 to February 2015 were selected and randomly divided into the observation group （n=30） and the control group （n=30）. All of the patients were treated with routine anti-infection and nutritional support， strengthened sputum drainage， immune regulation， mechanical ventilation， symptomatic and supportive treatment. Based on this， the observation group were given Xuebijing injection anti-inflammatory treatment（50 mlq12h）. After 2 weeks of continuous administration， the changes of efficacy and inflammatory factors related indicators of the two groups were compare. Results In the observation group， the total effective rate was 90.0% which was significantly higher than 63.3% of the control group and the difference was statistically significant （P0.05）； After the treatment， serum IL-1 （118.67±9.01）pg/L， IL-6 （79.68±14.82）pg/L and TNF-α（13.68±5.41） mg/L decreased significantly， compared with those before the treatment. Compared with the control group， the descending level was significantly and the differences were statistically significant （P 　　1 资料与方法 　　1.1 一般资料 　　随机抽取2014年3月―2015年2月该院收治于ICU的重症肺炎患者60例，男37例，女