体外生物测定西西在新药开发中的应用.docVIP

体外生物测定及其在新药开发中的应用 沈嘉 摘　要：简介用体外模型以离体细胞或纯化酶测定试验样品，对受体及酶的拮抗或抑制作用的体外生物测定法在国外新药及标准提取物和日本汉方制剂研究开发过程中的应用。关键词：受体；酶；标准提取物；日本汉方药；拮抗剂；抑制剂 IN VITRO BIOASSAY AND ITS APPLICATIONS IN NEW DRUG DEVELOPMENT Shen Jia (Department of Traditional Chinese Medicines,ShenyangPharmaceutical University, Shenyang 110015) ABSTRACT：The applications of in vitro bioassay which util izes in vitro model,isolated cells or purified enzyme to measure the antagonisti c or inhibitive effects on receptor or enzyme,in development of new drug,standard ext ract and Japanese-Chinese traditional herbal medicine were briefly intro