非晶态雷尼镍论文：-酒石酸修饰RaneyNi催化樟脑不对称加氢合成龙脑.docVIP

非晶态雷尼镍论文：D-酒石酸修饰RaneyNi催化樟脑不对称加氢合成龙脑 【中文摘要】手性化合物是一类重要的化合物,在香料、医药、农药和功能材料等方面具有广泛用途。开展手性合成的新方法和新催化剂的研究具有十分重要的意义。多相手性催化剂具有产物易分离,催化剂可以重复使用等优点,符合绿色化学发展方向。因此近年来开发和探索高效率、高光学选择性的的多相手性催化剂已成为手性催化研究的重要课题。采用具有光学活性的酒石酸修饰雷尼镍催化剂可以制得一种高效催化剂,该催化剂体系对羰基手性加氢具有良好的催化活性和对映体选择性。本课题将该催化体系用于催化天然樟脑不对称 【英文摘要】Chiral compounds are important compounds,which are broadly used in perfume,medicine,pesticide,functional materials and so on.It has great importance to produce new method and new catalyst for chiral synthesis.There are two kinds chiral catalyst,homogeneous and heterogeneous phase catalyst.Homogeneous phase catalyst has high reaction activity and enantio-selectivity,but it抯 expensive and hard to reuse. Hetero-geneous phase catalysts are facile,easy operated and easy to reused, which are as green chemical catalyst.So it is important subject to develop new catalyst with high reaction activity and enantioselectivity.The system of Raney Ni modified by D-tartaric acid high reaction activity and enantio-selectivity on carbonyl compounds hydrogenation.Our subject trys to use RaneyNi/D-TA/NaBr as catalyst in hydrogenation of comphor.This is the main research contents:(1)Find new technical route. By read many abstract, we decide our technical route as this:research the effects of D-tartaric acid concentration,pH of modifying solution,selection of additives,temperature of modification and time of modification on Raney nickel catalyst.We find optimum modification conditions as: Raney Ni 3g, modified in 100ml solution with 1% D-tartaric acid concentration and 2% NaBr concentration,pH =4,which are achieved by adding1M NaOH,then modified 1hour at 100℃.(2)The influence of most important factors on the optical yield and hydrogenation activity varying the reaction temperature and pressure,solvent type,the reaction time and so on were systematically investigated.By many tests,We find optimum conditions as this:comphor 3g,modified Raney Ni 3g,ethanol-solution 500ml,acetoacetate2g,stirring speed as 800r/min,r