400吨年L-谷氨酰胺生产工艺的设计说明书调研报告.docVIP

学号： 常 州 大 学 毕业设计书 （2014届） 题 目 吨/年L-谷氨酰胺生产工艺的设计 学 生 学 院 制药与生命科学学院 专业班级 生工 校内指导教师 王利群 专业技术职务 副教授 二○ATCC14067SGR突变株发酵生成L-谷氨酰胺，发酵液经絮凝和过滤后，进入活性炭柱脱色，接着进行第一次浓缩结晶，晶体溶解后进行电渗析脱盐，再利用D330树脂进行离子交换，洗脱液输送至浓缩结晶罐中，进行第二次浓缩结晶，通过过滤得到晶体，晶体干燥后得到L-谷氨酰胺成品，总提取率为73%。 本设计在查阅大量资料的基础上，进行了工艺物料计算、能量衡算、设备选型、管道计算、投资估算及经济分析，结果表明总投资为1999.32万元，投资回收期为3.41年。在此基础上，还绘制了物料流程图、带控制点工艺流程图、车间平面布置图和主要设备条件图。 关键词 ：L-谷氨酰胺；发酵法；工艺设计；经济分析 The design of 400T/a L-glutamine production process Abstract: L-glutamine is one of the 20 essential amino acids in constituting human proteins. As the most abundant essential amino acids of free amino acids in human body, L-glutamine is mainly stored in the brain, skeletal muscles, blood and it has a wide range of physiological effects. After comparing the current international and domestic L-glutamine producing methods and processes, a mutant strain of Brebvibacterium (Brebvibacterium ATCC14067SGR) was chosen to fermente L-glutamine.After flocculation and filtration, fermentation broth was transport into active carbon column to decolor, then the eluent was processed by concentration and crystallization for the first time. After the crystals dissolved, electrodialysis desalinization was carried out. the reaction fluid was absorbed by ion exchange resin D330. Then the eluent with L-glutamine was transported to the concentration crystal tank for the second concentration and crystallization. Filter to get crystals, dry, get finished product L-valine.The overall yield is 73%. In this paper, the material balance, the energy balance, equipment selection,pipeline calculation,investment estimate and economic analysis were conducted based on a large number of documents and papers about L-valine production. The financial analysis and evaluation indicated that the total investment is RMB 19.9932 million yuan and the investment returm period is 3.41 years. Based on above c