Sepsis-3资料.pptVIP

Sepsis和Septic Shock 新定义;Sepsis 定义的发展过程;Sepsis-1;Sepsis-1;SIRS标准的特异性过低 ;SIRS Criteria in Defining Severe Sepsis;Sepsis definitions: time for change ;Sepsis-2;中国2014脓毒症的诊断标准;The Third International Consensus Definitionsfor Sepsis and Septic Shock (Sepsis-3); The original conceptualization of sepsis as infection with at least 2 of the 4 SIRS criteria focused solely on inflammatory excess. However, the validity of SIRS as a descriptor of sepsis pathobiology has been challenged. ; Importance; Objective; Process; Definition; For clinical operationalization; SOFA for clinical operationalization;; Components of SOFA (such as creatinine or bilirubin level) require laboratory testing and thus may not promptly capture dysfunction in individual organ systems. Other elements, such as the cardiovascular score, can be affected by iatrogenic interventions.; Although qSOFA is less robust than a SOFA score of 2 or greater in the ICU, it does not require laboratory tests and can be assessed quickly and repeatedly. ; Patients with septic shock can be identified with a clinical construct of sepsis with persisting hypotension requiring vasopressors to maintain MAP≥65mmHg and having a serum lactate level2 mmol/L despite adequate volume resuscitation. ;Operationalization of Clinical Criteria Identifying Patients With Sepsis and Septic Shock;脓毒症和脓毒性休克的临床诊断流程;Sepsis 3.0=感染+SOFA≥2;你好SOFA! 再见SIRS!