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Outcomesforpatientswithpapillarythyroidcancerwhodonot.docx

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Outcomesforpatientswithpapillarythyroidcancerwhodonot.docx

Outcomes for patients with papillary thyroid cancer who do not undergo prophylactic neck dissection I. J. Nixon1, L. Y. Wang1, I. Ganly1, S. G. Patel1, L. G. Morris1, J. C. Migliacci1, R. M. Tuttle2, J. P. Shah1 and A. R. Shaha1 1Head and Neck Surgery and 2Department of Endocrinology, Memorial Sloan Kettering Cancer Center, New York, USA Correspondence to: Dr I. J Nixon, Head and Neck Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY?10021, USA (e-mail: iainjnixon@) Introduction: The role of prophylactic central neck dissection (CND) in the management of papillary thyroid cancer (PTC) is controversial. This report describes outcomes of an observational approach in patients without clinical evidence of nodal disease in PTC. Methods: All patients who had surgery between 1986 and 2010 without CND for PTC were identified. All patients had careful clinical assessment of the central neck during preoperative and perioperative evaluation, with any suspicious nodal tissue excised for analysis. The cohort included patients in whom lymph nodes had been removed, but no patient had undergone a formal neck dissection. Recurrence-free survival (RFS), central neck RFS and disease-specific survival (DSS) were calculated using the Kaplan–Meier method. Results: Of 1798 patients, 397 (22.1 per cent) were men, 1088 (60.5 per cent) were aged 45?years or more, and 539 (30.0 per cent) had pT3 or pT4 disease. Some 742 patients (41.3 per cent) received adjuvant treatment with radioactive iodine. At a median follow-up of 46?months the 5-year DSS rate was 100 per cent100.0 . Five-year RFS and central neck RFS rates were 96.6 and 99.1 per cent respectively. Conclusion: Observation of the central neck is safe and should be recommended for all patients with PTC considered before and during surgery to be free of central neck metastasis. +A: Introduction Lymph node metastasis in papillary thyroid cancer (PTC) is common HYPERLINK \l _ENREF_1 \o Shaha, 1996 #18 ADD