病毒感染与自身免疫病课题.pptVIP

病毒感染与自身免疫病 ; Virus Infections and autoimmunity Exogenous viruses: EBV Molecular mechanism for autoimmunity Enogenous viruses : HERV Autoimmune disease: A role for new anti-viral therapies?; Virus Infections and autoimmunity (Background);少数T细胞克隆逃 避阴性选择 进入外周;B细胞发育过程自身耐受形成及逃避机制;Host MHC Loss of Tolerance Immune system defects Susceptibility Genes Endogenous Viruses Autoimmune disease ;;;Exogenous viruses;Exogenous viral agents have also been implicated as potential triggers or pathogenic agents of autoimmune conditions. Viruses which have been linked to the pathogenesis of SLE include ： Epstein-Barr Virus (EBV) Cytomegalovirus (CMV), parvovirus (细小) B19 Human Papilloma Virus (HPV), Human Herpes Virus (HHV-6), HHV-7, HHV-8, Dengue virus HIV human T cell lymphotropic virus (HTLV,人类嗜T细胞病毒 ) ;EBV as a potential viral agent in SLE;EBV 结构和蛋白;增殖性感染表达的抗原;潜伏性感染表达的抗原;;Immunological Mechanisms for Autoimmunity;Molecular mimicry;EBNA-1;李玲玲，朱珊丽，李文姝，薛向阳，张丽芳* EBV核蛋白-1B细胞表位的预测及其同源性分析 生物医学工程学杂志 2011，28（2）：371-375;LMP1;;Bystander Activation（旁路激活）;抗微生物 抗体;Epitope Spreading（表位扩展）;Polyspecific B-cell Activation;Accumulation of EBV-specific CD8+ T-cells in Sites of Inflammation;Transactivation of Human Endogenous Retroviruses ;Enogenous viruses : Human Endogenous Retroviruses （HERV） ;Human Endogenous Retroviruses （HERV）;几百万年前，HERV感染人类的生殖细胞，从而成为宿主遗传基因组的一部分。遗传给宿主的子孙后代。; Schematic representation of HERV-K10. Insert: electron micrograph (magnification: 15,000) of HERV-K particles budding from a teratocarcinoma（畸胎瘤） cell line TERA-1.;HERVs;HRES-1;Figure 3 (a) Molecular models of a homologous epitopes located on SmD1 and HRES-1. (b) Amino acid sequence homology between HRES-1 gag and SLE autoantigens.;ERV-3，HERV-E 4-1;HERV K10;HERV与系统性红斑狼疮的关系;HERV与类风湿