童癫痫的临床治疗要点.pptVIP

Levision PM, et al. Neurocognitive effects of adjunctive letiracetam in children with partial-onset seizures: A randomized, double-blind, placebo-controlled, noninferiority trial Epilepsia. 2009; 50(11): 2377-2389 这是一项随机、双盲、安慰剂对照的左乙拉西坦对儿童和青少年患者认知功能影响的研究。经过12周治疗后，采用WRAML-2方法评价认知功能的变化。在总体记忆、视觉记忆、言语记忆和精神集中力等方面，左乙拉西坦都与安慰剂相似。 Summary Purpose:? Evaluate potential neurocognitive effects of adjunctive leveetiracetam in children with inadequately controlled partial-onset seizures (POS). Methods:? Randomized, double-blind, placebo-controlled, noninferiority safety study. Children (4–16?years; IQ ≥65)