铜绿假单胞菌感染的流行趋势及治疗进展.pptVIP

Antimicrobial therapy and control of multidrug-resistant Pseudomonas aeruginosa bacteremia in a teaching hospital in Taiwan. Leung CH, METHODS: MDR P. aeruginosa isolates were collected at the MacKay Memorial Hospital, Taipei, Taiwan, and antibiotic synergy was investigated based on antibiotic susceptibility tests using a combination of antibiotics. Isolates of patients with MDR P. aeruginosa bacteremia were selected for genetic analysis by pulsed-field gel electrophoresis. RESULTS: A combination of ceftazidime, amikacin, and sulbactam had significant synergistic effects against bloodstream MDR P. aeruginosa isolates and was more beneficial clinically compared with other antibiotic combinations. The major source of MDR P. aeruginosa infection was located and stringent infection control measures were enforced. CONCLUSION: The results of this study suggest that use of triple antimicrobial therapy (ceftazidime, amikacin, and sulbactam) can be a useful alternative treatment for MDR P. aeruginosa infection in certain circumstances. DiviJ Microbiol Immunol Infect. 2008 Dec;41(6):491-8. 3药联合治疗 头孢他啶+阿米卡星+舒巴坦治疗MDR-PA 感染是不错的选择。 Fosfomycin for the treatment of infections caused by multidrug-resistant non-fermenting Gram-negative bacilli: a systematic review of microbiological, animal and clinical studies. In six clinical studies, 33 patients with MDR P. aeruginosa infec-tions (mainly pulmonary exacerbations of cystic ?brosis) received fosfomycin (25/33 in combination withother antibiotics); 91% of the patients clinically improved. In conclusion, fosfomycin could have a role as a therapeutic option against MDR P. aeruginosa infections. Further research is needed to clarify the potentialutility of this agent. 联合治疗 磷霉素联合其他抗菌药物可以作为治疗MDR-PA感染的备用选择方案 Matthew E. Falagas. International Journal of Antimicrobial Agents 34 (2009) 111–120 Current treatment of pseudomonal infections in the elderly. In the elderly, in addition to making d