Rad51proteinisaberrantlyexpressedinhumanSTSsamples.ppt

Rad51 protein is aberrantly expressed in human STS samples of different histologic subtypes and stage. Jonathan A.F. Hannay et al. Mol Cancer Ther 2007;6:1650-1660 ?2007 by American Association for Cancer Research Rad51 protein is aberrantly expressed in human STS samples of different histologic subtypes and stage. Representative cases: A and B, primary malignant fibrous histiocytoma; C, primary rhabdomyosarcoma; D, metastatic rhabdomyosarcoma; E, recurrent alveolar soft part sarcoma ASPS ; F, metastatic fibrosarcoma; G, primary liposarcoma; H, normal tissue adjacent to an malignant fibrous histiocytoma exhibiting no Rad51 expression no tumor is seen in this slide . Immunohistochemistry done as per Materials and Methods. All original images were captured at ×200 magnification. I, Rad51 Western blot exhibiting increased Rad51 expression in protein extracted from selected human STS specimens when compared with expression in matched normal tissue.