肿瘤的表观遗传调控幻灯片.pptVIP

肿瘤的表观遗传调控 ( Epigenetic Regulation of Cancer) Chromatin packaging 表观遗传学概念 表观遗传(epigenetics)的概念是在1942年由Waddington提出。指DNA序列不发生变化但是基因表达却发生了可遗传的改变，也就是说基因型未变化而表型却发生了改变，这种变化是细胞内除了遗传信息以外的其他可遗传物质的改变，并且这种改变在发育和细胞增殖过程中能稳定地传递下去。 Cancer epigenetics In addition to having genetic causes, cancer can also be considered an epigenetic disease. Regulation by genetics involves a change in the DNA sequence, whereas epigenetic regulation involves alteration in chromatin structure and methylation of the promoter region 表观遗传修饰从多个水平调控基因表达 Enzymatic methylation of the C–5 position of cytosine residues