Toll-LikeReceptor4DeficiencyImpairsMicroglialPhagocytosisof.pptVIP

公文庆 Microglia introduction A type of microphage innate immune response 5—20% Neuron degeneration Imbalance distribution(海马嗅叶基底神经节多，小脑脑干分布少） background Despite emerging evidence that axonal debris can pose a barrier to regeneration of new axons in the CNS, little is known of the cellular and molecular mechanisms that underlie clearance of degenerating CNS axons. method We utilize a custom micropatterned microfluidic system that enables robust microglial-axon coculture to explore the role of Toll-like receptors (TLRs) in microglial phagocytosis of degenerating axons. Pharmacologic and genetic