【精品医学论文】早期2型糖尿病中西医联合强化治疗方案的临床研究.docVIP

早期2型糖尿病中西医联合强化治疗方案的临床研究疙北嬖侈咄瘟?眉踢吞奔【摘要】? 目的 初步建立针对早期2型糖尿病患者的中西医联合强化治疗方案,得到该方案的2型糖尿病缓解率,并探讨各因素与缓解率的相关性；同时,进一步探讨中药健脾清化方在保护胰岛β细胞功能、提高缓解率方面的作用。方法 观察47例早期2型糖尿病患者接受短期中药联合胰岛素泵强化治疗后的缓解率,采用logistic回归分析及组间对照分析各因素与缓解率的相关性,比较缓解组中强化结束时与随访时的胰岛β细胞功能及中药在诱导缓解率方面的影响。结果 强化治疗(11.8±2.5)d后,影响缓解率的主要因素为体重指数(P＝0.044)及达标总天数与总强化天数的比值(P＝0.00)；强化结束时、1个月、随访期(平均6个月左右)的缓解率分别为46.8%、55.3%、53.3%；随访期中药组与对照组的缓解率分别为66.7%、44.4%。结论 针对早期2型糖尿病患者的中西医联合强化治疗方案可使50%左右的患者获得临床缓解；中药对获得临床缓解及延长蜜月期有积极影响。 辫秆鸫跑谁狭宴挲剡衙颖 【关键词】? 早期2型糖尿病；中西医强化治疗；缓解率；胰岛β细胞；蜜月期鹈钉讨绒肮鲫缧桓车昱顽 ??? Abstract：Objective To investigate the remission rate of the therapy of integrated TCM into intensive insulin treatment, and the relationship between each factor and the remission rate. The effect of TCM on improving β-cell function and remission rate was also studied. Methods Forty-seven newly diagnosed type 2 diabetic patients were shortly treated with both continuous subcutaneous insulin infusion (CSII) and Chinese medicine. The remission rate was observed. The relationship between each factor and remission was analyzed by logistic regression. The β-cell function of patients in remission group were evluated at the end of the treatment and during the period of follow-up. Results After treatment of (11.8±2.5)d, BMI and the ratio of the days of blood glucose reaching the standard and the total treatment days were the mainly factors affecting the remission. The remission rate at the end of treatment, one month after treatment and follow-up period (about six month) was 46.8%, 55.3%, 53.3% respectively. In following up, the remission rate in the Chinese medicine group and the control group was 66.7%, 44.4% respectively. Conclusions About half of newly diagnosed type 2 diabetic patients obtain clinical remission after the short-term intensive treatment of integrated insulin and Chinese medicine. Chinese medicine may have positive impaction on remission and extending honeymoon period.铱她链屑暾咭垄烬蟥旯鹫 ??? Key words：newly diagnosed type 2 diabetes mellitus；intensive t