分析癫痫伴觉醒期大发作的临床表现(精选).docVIP

　　Clinical manifestations of analysis of epilepsy with grand mal Awakening （分析癫痫伴觉醒期大发作的临床表现） Generalized tonic-clonic seizures GTCS , also known as grand mal GM , can be seen in a variety of epilepsy syndrome caused by a variety of causes, both idiopathic generalized seizures, partial seizures may also be secondary GTCSmainly to other seizure types, GTCS often does not have a specific, not the main basis for the diagnosis of epilepsy syndrome type. Currently only one in the onset of adolescence to attack mainly appear soon after awakening GTCS has been identified as an idiopathic generalized epilepsy syndrome, epilepsy with grand mal Awakening EGMA . 全身强直一阵挛性发作 GTCS 又称大发作 GM ，可见于由各种病因引起的多种癫痫综合征，既可为特发性全身性发作，也可由局部性发作继发GTCS，因此当以其他发作类型为主时，GTCS往往不具有特异性，不是诊断癫痫综合征类型的主要依据。目前只有一种在青少年期发病，发作主要出现在觉醒后不久的GTCS被确定为一种特发性的全身性癫痫综合征，即癫痫伴觉醒期大发作 EGMA 。 　EGMA idiopathic epilepsy syndrome. Occurred during sleep, wake state and the awakening of the GTCS research shows that the majority of the Awakening GTCS etiology can be found. EGMA patients with familial febrile seizures or epilepsy occurs in sleep and awake big attack patients was significantly higher with the children and juvenile absence epilepsy, juvenile myoclonic epilepsy and other idiopathic generalized epilepsy , suggesting that the incidence of this disease with genetic susceptibility to convulsions. EGMA为特发性癫痫综合征。对发生在睡眠中、醒觉状态和觉醒期的GTCS的研究显示，觉醒期的GTCS大多数无病因可寻。EGMA患者家族中有热性惊厥或癫痫者比发生在睡眠中和清醒状态的大发作患者明显增高，而与儿童及少年失神性癫痫、少年肌阵挛性癫痫等其他特发性全身性癫痫相似，提示本症的发病与遗传性惊厥易感性有关。 　In addition to the inherent genetic predisposition, some external factors in the onset of EGMA induced or facilitated. The most important predisposing factor for the lack of sleep, such as deprivation of sleep or chronic lack of sleep. Polysomnography studies have shown that, the patients sleep EGMA especially unstable and vulnerable to external factors. In addition, light stimulation, fatigue, alcoholism is also likely to cause seizures. 　除内在的遗传易感性外，一些外在的因素对EGMA的发作具有诱发或易化作用。最