Protein modification and trafficking.pptVIP

Protein modification and trafficking There are two types of glycosylation Protein Glycosylation a-amalyase is produced in the parotid gland and is found in saliva How glucose gets into cells through the action of insulin Protein Glycosylation Where does Dolichol come from? Dolichol is an isoprenoid compound synthesized by the same metabolic route as cholesterol. In vertebrate tissues, dolichol contains 18-20 isoprenoid units (90-100 carbons total). Dolichol is phosphorylated by a kinase that uses CTP to form dolichol Phosphate. Dolichol phosphate is the structure upon which the carbohydrate m