磁性氧化铁纳米颗粒及其在MRI中的应用.pptx

Contents 第五章 阿瑞匹坦固体分散体和纳米混悬剂离体肠吸收研究 第三章 阿瑞匹坦纳米混悬剂的制备及药剂学性质研究 第一章 阿瑞匹坦体外分析方法的建立和理化性质研究 前言 第四章 阿瑞匹坦固体分散体和纳米混悬剂体内药动学研究 第六章 阿瑞匹坦固体分散体和纳米混悬剂Caco-2细胞跨膜转运研究 第二章 阿瑞匹坦纳米混悬剂的制备及药剂学性质研究 前言 第一章阿瑞匹坦体外分析方法的建立及理化性质研究 Company Logo S Introduction Structure of MRI functioned magnetic nanoparticles Introduction Preparation of MRI functioned magnetic nanoparticles Protection/Stabilization of Magnetic Particles Surface Passivation by Mild Oxidation Surfactant and Polymer Coating Precious-Metal Coating Matrix-Dispersed Magnetic Nanoparticles Silica Coating Carbon Coating Form a core-shell structure that isolate the core with the environment Protection/Stabilization of Magnetic Particles Surfactant and Polymer Coating ● Surfactants or polymers can be chemically anchored or physically adsorbed on magnetic nanoparticles to form a single or double layer which creates repulsive(mainly as steric repulsion) forces to balance the magnetic and the van der Waals attractive forces acting on the nanoparticles. Polymers containing functional groups, such as carboxylic acids, phosphates, and sulfates, can bind to the surface of magnetite. ● Protection/Stabilization of Magnetic Particles Surfactant and Polymer Coating Protection/Stabilization of Magnetic Particles Surfactant and Polymer Coating(chemical combination) Example: FeCo/graphitic-shell nanocrystals as advanced magnetic-resonance-imaging and near-infrared agents Protection/Stabilization of Magnetic Particles Surfactant and Polymer Coating(chemical combination) Protection/Stabilization of Magnetic Particles Surfactant and Polymer Coating(chemical combination) Protection/Stabilization of Magnetic Particles Example: Magnetite-loaded polymeric micelles as ultrasensitive magnetic-resonance probes Surfactant and Polymer Coating(physical combination) Protection/Stabilization of Magnetic Particles Surfactant and Polymer Coating(physical combination) Protection/Stabilization of Magnetic Particles Example: Maghemite Nanoparticles Protectively