吸烟对氨氯地平的降压疗效、炎性因子与动脉硬度的影响.pdfVIP

吸烟对氨氯地平的降压疗效、炎性因子和动脉硬度的影响 摘要： 目的：探讨吸烟对氨氯地平的降压疗效、相关炎性因子MCP．1、 Hs．CRP、ADP及BaPWV和ABI的影响。 方法：选取120例轻中度男性高血压患者，分为吸烟组和不吸烟 组，每组各60例，观察两组患者服用氨氯地平12周(5 mg，Qd)后的 降压疗效以及治疗前后MCP一1、Hs—CRP、ADP、BaPWV和ABI的 变化。并选择60名体检正常的男性不吸烟者作为对照组。采用ELISA 法测定MCP．1、Hs—CRP、ADP的含量，动脉硬化检测仪测定研究者 双侧BaPWV及ABI。 结果：1．与对照组相比，高血压不吸烟组MCP一1、ADP、Hs—CRP、 BaPWV均有显著升高，但ABI尚未达到统计学差异，而吸烟组上述 各指标均达到统计学差异(PO．01)。高血压吸烟组MCP．1、BaPWV 均高于不吸烟组，ADP、ABI均低于不吸烟组，上述指标均具有统计 学差异(PO．0 1)，但两组之间Hs．CRP比较无统计学差异(PO．05)。 2．经氨氯地平治疗后吸烟组与不吸烟组降压总有效率分别为53．3％、 60％，组间比较无统计学差异(PO．05)。3．与治疗前比较，经氨氯 地平治疗后吸烟组只有Hs—CRP达到了统计学差异，而不吸烟组 MCP．1、Hs．CRP、ADP的改变均有统计学差异。4．经氨氯地平治疗 后不吸烟组BaPWV、ABI较治疗前均有统计学意义，而吸烟组无明 显改变。 结论：1．男性高血压病患者的炎症因子水平和动脉硬化程度明显 升高，吸烟可进一步加重这种改变；2．吸烟对服用氨氯地平的轻中度 男性高血压患者的降压疗效无明显影响；3．氨氯地平在降压的同时， 还对男性高血压患者的炎症状态及动脉硬度有改善作用，但吸烟可降 低这种效应。 图3幅，表6个，参考文献67篇。 关键词：吸烟；原发性高血压；单核细胞趋化蛋白．1；高敏c．反应蛋 白；脂联素；肱踝脉搏波传导速度；踝臂指数 分类号：11544．1 II The effects of smoking on the antihypertensive efficacy，inflammatory factors and arterial stiffness of amlodipine ABS’l’RAC’I’： Objective：To evaluate the effects of smoking on the antihypertensive efficacy and MCP一1，Hs—CRP，ADP and BaPWV，ABI of amlodipine． Methods：We selected 1 20 cases of mild to moderate male hypertensive patients，and they were divideded into smoking group(60 cases)and non—smoking group(60 cases)．And all patients took amlodipine(5 mg，Qd)for 1 2 weeks．Antihypertensive effect and the level of MCP一1，Hs—CRP，ADP，BaPWV，ABl were observed before and after treatment．And we selected 60 male who were non．smokers and whose physical examination were normal at the same time as a control group．MCP一1，Hs—CRP，ADP level were detected by ELISA，BaPWV and ABl were measured by arteriosclerosis detector． Results：1．Compared with the control group，the level of MCP-1， ADP,Hs·-CRP and BaPWV in the non--smoking group were markedly different，but the level of ABI had no significant difference between the two groups，and all indicators in the Hypertension-smoking group had reached a significant difference(PO．0 1)．The level of MCP一1，BaPWV in the Hypert