drugs for CHF.pptVIP

Chapter 22 Drugs for Congestive Heart Failure (抗心功不全药) Department of pharmacology 辛志伟 PROBLEMS 1. Which kinds have drugs for CHF? 2.How to cause their effects each kind of drugs for CHF? 3.Which effects, usages and adverse effects have cardiac glycosides? 4. How to prevent and cure poisoned by cardiac glycosides? Sect.1 Introduction Ⅰ. Concept： 慢性(充血性)心力衰竭(chronic or congestive heart failure，CHF)：是由多种原因引起的心输量绝对或相对减少，不能满足全身组织代谢需要的一种病理生理状态或临床综合征。 Ⅱ. The pathophysiology of CHF 1.心肌结构与功能的变化 1）结构变化：心肌细胞凋亡增加，心肌组织纤维化 重构；顺应性降低。 Prevention and cure measures 1.避免和纠正诱发因素：