满穗(噻呋酰胺)介绍.ppt

Thifluzamide International Operations Nissan Chemical Key Features – Thifluzamide Systemic Fungicide Preventative and curative fungicidal efficacy Very safe to treated plants Long residual control Very effective as GR against Rice Sheath Blight Nursery box treatment is major application in Japan Moderate risk level of resistance development Low risk against Rhizoctonia especially Key Background – Thifluzamide Discovered by Monsanto originally Sold to Rohm Haas in 1994 Added to DAS fungicide portfolio in 2001 Acquired by Nissan Chemical in 2010 Registered in many crops in multiple countries Trade Names -Pulsor, Ikaruga, Greatam Chemistry - Thifluzamide Chemical Name (IUPAC) : 2’, 6’ –dibromo-2-2methyl-4’-trifluoromethoxy -4-trifluoromethyl -1, 3-thiazole-5-carboxanilide Common Name: Thifluzamide Code Number: MON 24000, RH-130753 Chemical Class: Carboxanilide Molecular: C13H6Br2F6N2O2S Molecular weight: 528.1 Vapor Pressure: 1.008 x 10-6 mPa Water Solubility: 1.6ppm (pH5.7), 7.6ppm (pH9) Aqueous Photolysis: 3.6 – 3.8 days (DT50) Melting Point: 177.9-178.6℃ (Pure Compound) Mammarian Safety - Thifluzamide Acute Oral LD50 (rat): 6,500mg/kg Acute Dermal (rabbit): 5,000mg/kg Acute Inhalation LC50 (rat): 5mg/L Primary Dermal Irritation (rabbit): slightly irritating Primary Eye Irritation (rabbit): slightly irritating Dermal Sensitization (guinea pig): not a sensitizer Not teratogenic, not genotoxic, not oncogenic Acceptable Daily Intake: RfD 0.014 mg/kg daily Environmental Safety - Thifluzamide Avian Acute Oral LD50 Bobwhite Quail Mallard Duck 2,250 mg/kg Acute Dietary LC50 Bobwhite Quail Mallard Duck 5,620 mg/kg Avian Reproduction Bobwhite Quail (NOEC/LOEC) 320/800 mg/kg Mallard Duck 800 mg/kg Fish Acute Toxicity LC50 Rainbow Trout and Bluegill Sunfish 1.3 ppm Carp 2.9 ppm Fish Chronic Aquatic Rainbow Trout Early Life Stage 0.31 (NOEC) 0.60 (LOEC) Acute Toxicity Daphnia 1.4 ppm Acute Oral Toxicity LD50 Honeybee