二甲双胍和阿格列汀联合吡格列酮治疗2型糖尿病效果观察.docVIP

二甲双胍和阿格列汀联合吡格列酮治疗2型糖尿病效果观察 　　【摘要】 目的：通过对比二甲双胍、苯甲酸阿格列汀联合盐酸吡格列酮与二甲双胍、盐酸吡格列酮联合阿卡波糖治疗2型糖尿病的临床效果，分析二甲双胍、苯甲酸阿格列汀联合盐酸吡格列酮治疗2型糖尿病的临床应用价值。方法：选取2013年6月-2015年1月在笔者所在医院住院治疗的2型糖尿病患者52例作为研究对象。随机分为两组，对照组患者采取二甲双胍、盐酸吡格列酮联合阿卡波糖治疗；试验组患者采取二甲双胍、苯甲酸阿格列汀联合盐酸吡格列酮治疗。结果：试验组患者的临床总有效率为96.0%，对照组患者的临床总有效率为80.0%，两组患者的临床总有效率比较差异有统计学意义（P0.05）；治疗后空腹血糖（FPG）、餐后2 h血糖（2 h PG）、体质指数（BMI）及糖化血红蛋白（HbA1c）相比差异均有统计学意义（P0.05）；治疗前后两组患者各项血糖指标相比差异均有统计学意义（P0.05）。结论：二甲双胍、苯甲酸阿格列汀联合盐酸吡格列酮治疗2型糖尿病通过降低肝糖生成、改善胰岛素敏感性以及升高体内胰升糖素样肽-1的浓度并恢复其刺激胰岛素分泌的作用等途径来控制血糖，疗效显著，具有一定的临床应用价值。 　　【关键词】 二甲双胍； 苯甲酸阿格列汀； 盐酸吡格列酮； 2型糖尿病 　　中图分类号 R587.1 文献标识码 A 文章编号 1674-6805（2016）5-0013-03 　　【Abstract】 Objective：To analyze the clinical application value of Alogliptin Benzoate and Metformin combined with Pioglitazone Hydrochloride in treatment of type 2 diabetes；through compare the clinical effect of Metformin，Alogliptin Benzoate combined with Pioglitazone Hydrochloride and Metformin，Pioglitazone combined with Acarbose in treatment of type 2 diabetes.Method：52 cases with type 2 diabetes admitted in our hospital from June 2013 to January 2015 were selected as the study object.They were randomly divided into two groups.The control group was treated with Metformin，Pioglitazone combined with Acarbose.The experimental group was treated with Metformin，Alogliptin Benzoate combined with Pioglitazone Hydrochloride.Result：The total effective rate of the experimental group was 96.0% and that of control group was 80.0%，the difference between two groups was statistical significance（P0.05）.After treatment，fasting plasma glucose（FPG），postprandial plasma glucose（2 h PG），body mass index（BMI） and glycosylated hemoglobin（HbA1c） had statistical significance between two groups（P0.05）.The difference between two groups glycemic index had statistical significance（P0.05）.Conclusion：Metformin，Alogliptin Benzoate combined with Pioglitazone Hydrochloride treatment for type 2 diabetes by reducing hepatic glucose production，improve insulin sensitivity and pancreatic liter in