肾细胞癌的分类compressed.pptVIP

Classification of Renal Carcinoma Zhe Wang Department of Pathology, Xijing Hospital Fourth Military Medical University Renal Unit Case 1 37 yr male. History of cerebellar hemangioblastoma, renal tumor and cyst Gross：Tumor diameter 5X5X2.5cm，cut surface yellow Some cysts in the tumor Risk factor for Von Hippel Lindau syndrome Younger than 50 years Multifocal unilateral or bilateral tumors Family history of renal cancer or other VHL related tumor Germline mutation analysis Missense mutation of VHL gene on 3p25-26 Diagnostic Criteria for VHL Syndrome No family history Hemangioblastoma of CNS or