血清心肌酶谱在重性精神病患者中临床观1.docVIP

血清心肌酶谱在重性精神病患者中临床观察 何新云 龙宇雄 彭志娥 李惠芝 郭君英 湖南省安化县精神病防治院 湖南 安化 413522 【摘要】目的：探讨血清心肌酶谱 CK、LDH、CK-MB、AST、a-HBD 与重性精神病患者病情的变化关系,指导临床用药及预防并发症。方法：对符合中国精神障碍分类与诊断标准第3 版（CCMD－Ⅲ）诊断标准的60例住院重性精神病患者，分别于入院24h内和1周后进行血清心肌酶谱检测，并采用夏梅兰所译的“阳性症状量表（SAPS）”和“阴性症状量表 SANS [1]”评分比较,同时根据临床症状的缓解观察分析。结果 60例重性精神病患者入院24h内CK、LDH、CK-MB显著高于治疗后，其中肌酸激酶（CK）增高34例，占56.7%。乳酸脱氢酶（LDH）增高8例,占13.3%，肌酸激酶同工酶（CK－MB）增高3例，占5%。入院时CK和LDH同时增高的7例,占11.66%。同时用SAPS和SANS症状量表评分其减分率有明显变化。结论　重性精神病患者急性期血清心肌酶谱有56.7%的增高、以血清CK、LDH、CK-MＢ增高为多见，其病情严重程度,病程及用药与血清心肌酶谱的高低有显著关系 P 0.01 ，阳性症状（SAPS）和阴性症状（SANS）量表分值与心肌酶谱降低关系密切。故此，重性精神病患者进行心肌酶谱检测，对观察疗效、指导临床安全用药、防止心脑血管意外的发生具有临床意义。 【关键词】重性精神病；血清心肌酶；临床检验观察 【 abstract 】 objective: to study the serum myocardial enzyme CK, LDH, CK-MB, AST, a-HBD and heavy nature of mental illness condition changes relationship, guiding clinical drug and to prevent complications. Methods: to accord with Chinas mental disorders classification and diagnosis standard third edition CCMD-Ⅲ diagnosis standard 60 patients in hospital of heavy mental patients, within 24 h respectively admission and after 1 week serum myocardial enzyme detection, and by using the XiaMeiLan the translation of positive symptoms scale SAPS and negative symptoms scale SANS [1] score is, at the same time, according to the study to analyze the clinical symptom relief. Results 60 cases of heavy mental illness were admitted to the hospital within 24 h CK, LDH, CK-MB significantly higher after treatment, including creatine kinase CK heighten 34 cases, accounting for 56.7%. Lactate dehydrogenase LDH increase in 8 cases, 13.3%, creatine kinase isozymes CK-MB increase in 3, 5%. Admission CK and LDH also increase of 7 cases, accounting for 11.66%. At the same time use the SAPS and SANS symptoms rating scale the deduction rate are obviously different. Conclusion heavy mental illness in the acute phase of serum myocardial enzyme of increased by 56.7%, and serum CK, LDH, CK-MB for many see increased, its illness severity, duration and d