窒息新生儿血清胱抑素C和尿微量白蛋白检测的临床意义.docVIP

窒息新生儿血清胱抑素C和尿微量白蛋白检测的临床意义 　　【摘要】 目的 探讨窒息新生儿血清胱抑素C（Cys C）和尿微量白蛋白（UMA）联合检测的临床意义。方法 57例窒息新生儿， 其中轻度窒息31例为轻度窒息组， 重度窒息26例为重度窒息组， 另选同期25例健康新生儿为对照组， 分别于生后24 h内采集静脉血、生后2 d采集尿液检测血清Cys C和UMA水平。对比三组检测结果。结果 新生儿轻度窒息组和重度窒息组血清Cys C及UMA水平均较对照组明显升高， 差异均有统计学意义（P0.01）， 重度窒息组Cys C及UMA水平明显高于轻度窒息组， 差异均有统计学意义（P0.01）。结论 窒息新生儿血清Cys C和UMA水平与病情严重程度及肾功能损害密切相关， 联合检测两者水平对窒息新生儿肾损害的早期诊断有重要价值。 　　【关键词】 新生儿窒息；肾损害；血清胱抑素C；尿微量白蛋白 　　DOI：10.14163/j.cnki.11-5547/r.2016.09.010 　　Clinical significance of serum cystatin C and urine microalbumin detection in neonatal asphyxia QIU Han-yin. Department of Pediatrics， Dongguan City People’s Hospital， Dongguan 523000， China 　　【Abstract】 Objective To investigate clinical significance of serum cystatin C （Cys C） and urine microalbumin （UMA） by combined detection in neonatal asphyxia. Methods Among 57 newborn with neonatal asphyxia， there were 31 cases with mild asphyxia as mild asphyxia group， and 26 cases with severe asphyxia as severe asphyxia group. There were another 25 healthy newborn at the same period as control group. Their venous blood and urine were respectively taken in postnatal 24 h and 2 d for serum Cys C and UMA levels detection. Outcomes of detection were compared across the three groups. Results The mild asphyxia group and severe asphyxia group had obviously higher serum Cys C and UMA level than the control group， and their differences all had statistical significance （P0.01）. The severe asphyxia group had much higher serum Cys C and UMA level than the mild asphyxia group， and the differences all had statistical significance （P0.01）. Conclusion Serum Cys C and UMA level in neonatal asphyxia are closely related with severity and renal damage. Combined detection contains important value for early diagnosis of renal damage in neonatal asphyxia. 　　【Key words】 Neonatal asphyxia； Renal damage； Serum cystatin C； Urine microalbumin 　　新生儿窒息是导致新生儿脑瘫、智力障碍及死亡的主要原因之一。重度窒息会引起心肺脑等多脏器功能障碍， 尤以肾损害的几率最高[1， 2]。早期发现肾损害并及早干预治疗对改善患儿预后至关重要。新生儿窒息后肾损害的症状体征均不典型， 需借助实