联合检测血浆中BIRC5、MYC的自身抗体水平在宫颈癌诊断中价值分析.docVIP

联合检测血浆中BIRC5、MYC的自身抗体水平在宫颈癌诊断中价值分析 　　【摘要】 目的：探讨联合检测血浆中BIRC5、MYC的自身抗体水平在宫颈癌诊断中的价值，以期寻找早期诊断宫颈癌的新型肿瘤标志物。方法：选取2014年2月-2015年7月本院收治的宫颈癌患者91例作为宫颈癌组，另选取同期在本院体检的86例健康女性作为对照组。采用ELISA法检测两组外周血中BIRC5、MYC及BIRC5与MYC混合抗原的自身抗体水平，并进行组间比较。结果：宫颈癌组外周血中BIRC5、MYC自身抗体水平均高于对照组，比较差异均有统计学意义（P0.05）；ROC分析结果显示，BIRC5自身抗体检测的曲线下面积（AUC）、特异性、敏感性、阳性预测值、阴性预测值依次为0.680、91.28%、21.05%、66.48%、52.49%；MYC自身抗体检测的AUC、特异性、敏感性、阳性预测值、阴性预测值依次为0.662、89.64%、8.14%、44.65%、49.52%；BIRC5与MYC混合抗原的自身抗体水平检测的AUC、特异性、敏感性、阳性预测值、阴性预测值依次为0.752、92.34%、28.43%、73.58%、55.50%。结论：BIRC5、MYC自身抗体均与宫颈癌具有一定的相关性，BIRC5与MYC混合抗原的自身抗体检测诊断宫颈癌的敏感性和特异性明显优于单一抗原自身抗体检测，联合检测可提高检测效率。 　　【关键词】 宫颈癌； BIRC5； MYC； 混合抗原； 诊断 　　Value Analysis of Combined Detection of BIRC5，MYC Autoantibody Levels in the Diagnosis of Cervical Cancer/MAI Li-ping，MAI Zhi-zhou.//Medical Innovation of China，2016，13（10）：008-011 　　【Abstract】 Objective：To discuss the combined detection of BIRC5，MYC autoantibody levels in the diagnosis of cervical cancer in order to find a new type of tumor markers for early diagnosis of cervical cancer.Method：91 cases of patients with cervical cancer in our hospital from February 2014 to July 2015 were selected as cervical cancer group，and 86 cases of healthy women who took physical examination in our hospital at the same period were selected as control group.The plasma levels of BIRC5，MYC and BIRC5 mixed MYC（mixed antigen） autoantibody were detected and compared between the two groups.Result：Compared with the control group，the plasma levels of BIRC5，MYC autoantibody of the cervical cancer group were higher，the differences were statistically significant（P0.05）.ROC analysis showed that the AUC，specificity，sensitivity，positive predictive value，negative predictive value of BIRC5 autoantibody were 0.680，91.28%，21.05%，66.48%，52.49%，MYC autoantibody were 0.662，89.64%，8.14%，44.65%，49.52% and mixed antigen were 0.752，92.34%，28.43%，73.58%，55.50%.Conclusion：BIRC5，MYC autoantibody are correlated with cervical cancer.Combined detection of BIRC5，MYC autoanti