肺癌治疗新进展课稿.ppt

Cigarette smoke also contain TAR that? is responsible for the diseases of respiratory tract. It also contain benzo-pyrene that is carcinogenic, lead, arsenic, formaldehyde, hydro cyanide (poison)? a lot more. The smoking is of two types ACTIVE SMOKING PASSIVE SMOKING. Active smoking is the inhalation of cigarette smoke by smoker whereas Passive smoking is the inhalation of the exhaled cigarette smoke by the non smoker in the area where a smoker is smoking. Passive smoking is also dangerous as active smoking that results in the development of different health related problems. Smoking can cause Lung cancer Lung disease Low estrogen level for women Bladder cancer Oral cancer Heart diseases Stroke Hypertension Etc Some people say that the cigarette has nicotine which can elevate our mood, increase the ability to think, increase concentration to understand the things etc. For those people, nicotine is a CNS stimulant it activate the mind at low doses but it deactivate the mind (CNS) at high doses. Nicotine use for longer duration can also cause severe health problems like Addiction Tremors Intestinal cramps Increase heart rate High blood pressure Paralysis Constriction of blood vessels Now after the reading of this very short information you are in better position to decide the answer of the question which is the title of this article. * * 当前晚期NSCLC治疗方式的选择仍然很大程度上是根据经验来决定的。每当选定一个治疗方案，都需要考虑来自四个方面的因素：（1）来自文献的证据（例如：不同药物的疗效毒性比），（2）患者个体特征（例如：年龄，性别，体力状态评分，吸烟状态），（3）患者的意愿（例如：偏向于改善生存期还是改善生存质量），（4）医生的经验与偏好1。 虽然根据经验的治疗对很多病人也很有效，目前这个模式正在往向“个体化治疗”模式转变。近期出现的多种选择指标使这种转变成为可能：临床指标、组织学指标与分子指标1。 临床指标包括：女性，非吸烟者，亚裔，无咯血及脑转移，年龄70岁1。 组织学指标包括非鳞癌和鳞癌（咯血风险不同）1。 分子指标包括胸苷酸合成酶，ERCC1,RRM1，EGFR突变(+)，K-ras突变FISH(-)1。 参考文献： 1.Gandara DR, Lara PN Jr, Mack P, Scagliotti G. Individualizing therapy for non-small-cell lung cancer: a paradigm shift from empiric to integrated decision-making. Clin Lung Cancer. 2009;10:148-150. Are there baseline characteristics that predict whether bevacizumab will benefit a