anti-hypertensives.pptVIP

Chapter 25 Antihypertensive drugs (抗高血压药) PROBLEMS 1.What is the link and mechanism of action of each group antihypertensive drugs? 2.How to use antihypertensive drugs reasonably ? （Ⅱ）ARBs (AT1-R阻断药) Mechanism of action： Features： 不影响缓激肽代谢，故不引起刺激性干咳。其它不良反应与ACEI相似。 Application：同ACEIs Drugs used usually： 氯沙坦(losartan);缬沙坦(valsartan);厄贝沙坦(irbesartan);坎地沙坦(candesartan); 替米沙坦(temisartan) Calcium channels blockers used usually (Ⅱ) Drugs opening K+ channels (钾通道开放药) Mechanism of action： Features：选择性扩张冠脉、胃肠道血管和脑血管，而不扩张肾和皮肤血管。余同直接扩血管药。 Application：中度以上高血压 Drugs used usually： 米诺地尔(minoxidil)；