基金项目现代中药创新集群与数字制药技术平台（2013zx.docVIP

基金项目：现代中药创新集群与数字制药技术平台（2013Z） 消栓通络片与市售消栓通络片对大鼠局灶性脑缺血的 治疗作用对比研究* 李卓琼1，2，宗绍波1，2，周军1，2，王振中1，2，萧伟1，2** 1江苏康缘药业股份有限公司血清含量的Caspase-3的显著升高有一定抑制作用。与市售消栓通络片比较，改工艺消栓通络片从大鼠行为学评分的降低，血清SOD活性的增加，血清Caspase-3、NF-κB的表达效果均有优于市售消栓通络片的趋势。结论 改工艺消栓通络片各剂量组对脑缺血进展期大鼠均有一定的恢复作用，其药效略优于市售消栓通络片。 [关键词] 消栓通络；脑缺血；NF-KB；CASPASE-3 [中图分类号] R285.5 Compared the Difference of Effection of XiaoShuan TongLuo and Market XiaoShuan TongLuo Tablets on Rats with Focal Cerebral Ischemia* LI Zhuo-qiong1,2,ZONG Shao-bo1、2,ZHOU Jun1、2,WANG Zhen-zhong1、2,XIAO Wei**1、2 （1. Jiangsu Kanion Parmaceutical Co.,Ltd.; 2. State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Jiangsu Lianyungang 222001 China） Abstract Objective: To discuss the difference of effection of XiaoShuan TongLuo and market XiaoShuan TongLuo tablets on rats with focal cerebral ischemia. Method: Rat models with middle cerebral artery occlusion (MCAO) were established. The behavior and infarct size.The SOD activity,NF-κB and CASPASE-3 contents were measured. Result: Compared with the lower group, higher and middle dosage groups of XiaoShuan TongLuo (0.44 and 0.22 g·kg-1) could obviously decrease the scales of neurological behavior of MCAO rats remarkably,all group of XiaoShuan TongLuo could obviously increase the SOD of MCAO rats remarkably，and higher and lower dosage groups of XiaoShuan TongLuo could obviously decrease the NF-κB lever of MCAO rats. Middle and lower dosage groups of XiaoShuan TongLuo could obviously decrease the CASPASE-3 lever of MCAO rats.From the behavior decreased,SOD increased,the expression of serum caspase-3 and NF-κB have a certain inhibited, it is better than the market XiaoShuan TongLuo tablets. Conclusion: Each dose group of XiaoShuan TongLuo on cerebral ischemia in rats have some recovery action. Keywords XiaoShuan TongLuo ; cerebral ischemia-reperfusion; Caspase-3;NF-κB 消栓通络片是治疗中风恢复期的有效验方，有活血化瘀，温经通络的作用。临床常用于脑血栓引起的半身不遂，肢体麻木的治疗。我们对该方的传统制剂工艺进行了改进，将黄芪、三七、槐花、丹参四味药材由原工艺的水提改为60%醇提