Chinesescientistsgeneticallymodifyhumanembryos.docVIP

Chinese scientists genetically modify human embryos Rumours of germline modification prove true — and look set to reignite an ethical debate David Cyranoski Sara Reardon，22 April 2015，Nature Human embryos are at the centre of a debate over the ethics of gene editing. In a world first, Chinese scientists have reported editing the genomes of human embryos. The results are published in the online journal Protein Cell and confirm widespread rumours that such experiments had been conducted—rumours that? sparked a high-profile debate last month about the ethical implications of such work. 来自中国的科学家们报告他们编辑了人类胚胎的基因组，这可以说是世界首次。这些在线发表在《Protein??Cell》杂志上的研究结果证实了广为流传的谣言：已经有人在开展这类的实验——在上个月这些传闻引发了科学界对于这类工作伦理影响的激烈争论。 这项研究也引起了国际顶级期刊Nature网站的热点关注，4月22日Nature以“Chinese?scientists?genetically?modify?human?embryos”为题对此进行了新闻报道。 In the paper, researchers led by Junjiu Huang, a gene-function researcher at Sun Yat-sen University in Guangzhou, tried to head off such concerns by using non-viable embryos, which cannot result in a live birth, that were obtained from local fertility clinics. The team attempted to modify the gene responsible for β-thalassaemia, a potentially fatal blood disorder, using a gene-editing technique known as CRISPR/Cas9. The researchers say that their results reveal serious obstacles to using the method in medical applications. 在这篇论文中，中山大学基因功能研究人员黄军就（Junjiu?Huang）领导研究人员，试图通过利用“不能存活”的胚胎（从当地生殖诊所获得，无法生成活胎的胚胎）来回避这样的关注和担忧。该研究小组尝试利用CRISPR/Cas9基因编辑技术改造了导致一种潜在致命血液疾病——β-地中海贫血的基因。研究人员说，他们的研究结果表明将这种方法应用于医学用途存在一些重大的障碍（延伸阅读：《细胞》特辑：CRISPR/Cas9技术?）。 I believe this is the first report of CRISPR/Cas9 applied to human pre-implantation embryos and as such the study is a landmark, as well as a cautionary tale, says George Daley, a stem-cell biologist at Harvard Medical School in Boston. Their study should be a stern warning to any practitioner who thinks the technology is ready for testing to eradicate disease genes. 哈佛医学院干细胞生物学家George?Daley说：“我相信这是第一次报告将CRISPR/Cas9应用于人类植入前胚胎，就其