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simultaneouspetandmri-fda.ppt

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simultaneouspetandmri-fda

microPETExperiences with Small Animal PET Imaging Simon R. Cherry, Ph.D. Crump Institute for Biological Imaging Dept. of Molecular and Medical Pharmacology UCLA School of Medicine, Los Angeles, California Outline PET Basics motivation for small animal PET design performance of a small animal PET scanner applications for small animal PET Positron Emission Tomography Positron-Emitting Radionuclides PET-labeled Probes for Biological Imaging hemodynamic parameters H215O, 15O-butanol, 11CO, 13NH3..... substrate metabolism 18F-FDG, 15O2, 11C-palmitic acid.... protein synthesis 11C-leucine, 11C-methionine, 11C-tyrosine enzyme activity 11C-deprenyl, 18F-deoxyuracil... drugs 11C-cocaine, 13N-cisplatin, 18F-fluorouracil... receptor affinity 11C-raclopride, 11C-carfentanil, 11C-scopalamine neurotransmitter biochemistry 18F-fluorodopa, 11C-ephedrine... gene expression 18F-penciclovir, 18F-antisense oligonucleotides... ..................................... Human Whole-Body PET Scanners Time Course of 18F-FDOPA in the Brain Tracer Kinetic Modeling Why Small Animal Imaging? in vivo ? in vitro non-destructive - repeat studies in the same animal can efficiently survey whole animal rapid in vivo screening? provides bridge from animal studies to human studies better decisions sooner! In Vivo Small Animal Imaging Which Imaging Technique? what do you want to measure? spatial resolution μm or mm? temporal resolution ms or mins? sensitivity mM or nM? field of view striatum or whole animal? what’s available microPET Small Animal PET Scanner Development microPET UCLA/Concorde Microsystems HIDAC Oxford Positron Systems SHR-7700 Hamamatsu, Japan Sherbrooke Animal PET Sherbrooke, Canada RATPET MRC Hammersmith TierPET Jülich, Germany YAP-PET Ferrara, Italy MAD-PET Munich, Germany ANI-PET Montreal, Canada microPET images 18F-FDG Whole Body Rat Study 18F-FDG Rat Heart Mouse Brain:11C-WIN 35,428 Imaging Gene Expression by PET PET in Drug Development