ToxicResponsesintheKidney.pptVIP

Anatomical解剖 arrangement and organization of the nephrons肾单位 within the kidney 1 million nephrons in each human kidney Renal blood flow肾血流量 (RBF) 94% to cortex皮质 5% outer medulla髓质 1% inner medulla Three Basic functions of the nephron Filtration过滤 at the glomerulus 肾小球 Tubular reabsorption肾小管重吸收 Tubular secretion肾小管分泌 Amount excreted in urine = amount filtered + reabsorbed + secreted by tubules Organization of the Glomerulus Solute up to 10000 M.W. pass through the filter freely Diffusion is restricted and ceases around 70000 M.W. to 100000 M.W. For creatinine肌氨酸酐 P x GFR =