2009-HOGGITrials_Chiorean.ppt

Grade 3/4 Hypertension Is Associated With Improved Median OS in E2100 Median OS: 25.3 mo vs. 38.7 mo p 0.002 Schneider et al; J Clin Oncol, 2008 Future PREDICTIVE Biomarkers for Targeted Therapies in Colon Cancer EGFR MoABs K-Ras established! B-Raf Not ready for prime time PI3K mutations? PTEN? EGFR amplifications? Gene arrays under study ? VEGF MoAB Wide open VEGF polymorphisms? Colorectal Cancer Engineering Project Cancer Care Engineering Cyber Infrastructure Omics Lab Data Visualization, Analysis, Mining, Fusion Systems Analysis Clinicians Healthcare System Data Literature Situation Room Researchers Patient Samples Data Engineering “System Analysis” cancer patients and care delivery as the system Allows clinical data to drive discovery research DOD 0座机电话号码 and PCC-Regenstrief Foundation Rationale: CCE now METABOLOMICS GLYCO- PROTEOMICS LIPIDOMICS BIOMAP C R C GENOMICS Mathematical modeling DIET LIFESTYLE Rationale in colorectal cancer Perform OMICs of healthy, polyps, cancer Compare OMICs between cancer, polyps and healthy: develop new screening and risk assessment tools Analyse changes in OMICs with treatment and correlate with response/toxicity: predictive markers Mathematical modeling and bio-mapping Cancer care delivery Schema IUCRO-0221CCE in CRC active April 2009 S A M P L E S Blood Serum 7 mL red top Metab, vit D Blood Plasma 21 mL purple top Genomics, lipidomics, glycoproteomics N 270 Stratification: Healthy n 90 Polyps n 90 Cancer n 90 stg 1/2 stg 3 stg 4 metastatic Tissue 10 mg polyp or 50 mg cancer / 50 mg normal tissue S H I P D R Y I C E 8-hr fasting Samples Collection Healthy Controls Screening Colonoscopy – GI Clinic Sign ICS RN Label specimens Healthy if no polyps/tumor Collect by RN/processing CRS Blood 1x 7 mL glass red top 3 x 7 mL plastic lavender Questionnaires diet/environmental exposures Samples Collection Adenomatous Polyps Screening Colonoscopy – GI Clinic Sign ICS RN Label specimen