1 Molecular Diagnostics.pptVIP

MOLECULAR DIAGNOSITICS Prof. Fang Zheng, Tianjin Medical University Introduction to Molecular Diagnostics 1. Molecular Diagnosis 1. Molecular Diagnostics 1. Molecular Diagnostics 1. Molecular Diagnostics: Emergence The information revolution in molecular biology is permeating every aspect of medical practice The rate of disease gene discovery is increasing exponentially, which facilitates the understanding diseases at molecular level Molecular understanding of disease is translated into diagnostic testing, therapeutics, and eventually preventive therapies 1. Molecular Diagnostics: Significance 1. Molecular Diagnostics: Goal To introduce essential concepts in molecular diagnostics that impact on the identification of novel markers of human diseases To develop and apply useful molecular assays to monitor disease, determine appropriate treatment strategies, and predict disease outcomes. 2. History of Molecular Diagnostics 2. History of Molecular Diagnostics ? U.S. Government project coordinated by the Dept. of Energy and NIH ? Goals of the Human Genome Project (1990–2006) – To identify all of the genes in human DNA; – To determine the sequences of the 3 billion bases that make up human DNA; – To create databases; – To develop tools for data analysis; and – To address the ethical, legal, and social issues that arise from genome research 2. History of Molecular Diagnostics ? U.S. Government project coordinated by the Dept. of Energy and NIH ? Goals of the Human Genome Project (1990–2006) – To identify all of the genes in human DNA; – To determine the sequences of the 3 billion bases that make up human DNA; – To create databases; – To develop tools for data analysis; and – To address the ethical, legal, and social issues that arise from genome research 3. Impact on Human Diseases: Novelty Discovery of potential novel molecular markers of human diseases Identification of novel molecular markers of human diseases Utility of molecular markers to devel