高压氧综合治疗药物治疗突发性耳聋的对比研究.docVIP

高压氧综合治疗与药物治疗突发性耳聋的对比研究 黄 怀，古 菁，虞容豪，叶水林 （广州军区广州总医院高压氧科，广东，广州 510010） 摘 要：目的 比较不同治疗时窗高压氧综合治疗和常规药物治疗对突发性耳聋疗效的影响。方法196例突发性耳聋患者，随机分为高压氧综合治疗组（HBO组）和常规药物治疗组（对照组），对照组常规予以药物治疗，HBO组在常规药物治疗基础上同时进行高压氧治疗，分别在不同时窗对比治疗前后听力的变化。结果 在发病后24h内开始治疗，两组都可收到较好疗效；在发病24h后1w内开始治疗，HBO组比对照组疗效果好，差异有统计学意义（p0.05）；发病2w后开始治疗，两组治疗效果均较差。结论 高压氧综合治疗疗效显著，高压氧治疗可较好地改善突发性耳聋患者的听力水平，应于发病早期（1w）进行高压氧治疗。 关键词：突发性耳聋；高压氧；疗效 The Curative Effect Comparison Between Hyperbaric Oxygen And Medical Treatment Together With Medical Treatment in the Treatment Of Sudden Deafness Huang Huai, GU Jing, YU Rong-hao，YEShui-lin （Hyperbaric oxygen Department, Guangzhou General Army Hospital, Guangzhou 510010） To compare the therapeutic effects of hyperbaric oxygen (HBO) therapy and medical treatment (MT), respectively, and to investigate the influence of HBO therapeutic window on clinical outcome. Method 196 sudden deafness (SD) are divided into two groups, each contains 98 patients. One group is treated by combined therapy (include HBO therapy and medical treatment), this group define as HBO group. The other group is only treated by medical treatment, this group define as MT group. All patients were evaluated with an audiometric test before and after treatment. Results HBO therapy and MT had excellent effects on the patient of SD when the treatment was initiated within the first 24 hours. HBO therapy had better curative effect than MT within the first week. There was statistical difference between two groups. Both HBO therapy and medical treatment are hard of improving the outcome of SD after 2w. Conclusion HBO is highly efficient in improving audile outcome in SD. Important is to start the therapy quickly after hearing loss. Key words: Sudden deafness; hyperbaric oxygen; curative effect 突发性耳聋hyperbaric oxygen ，HBO）治疗是临床治疗SD的常用方法，效果明显[1]。我们分别采用HBO综合治疗和常规药物来治疗SD，对比其疗效，并分析影响治疗效果的若干因素，以指导临床更好地应用HBO治疗SD，现报道如下。 1 临床资料 1.1 一般资料 2006年6月至2009年4月收治的SD住院患者196例，随机分为两组，其中HBO组98例，男性53例，女性45例。平均年龄（46.42±17.13）周岁，范围：23~63周岁。从发病到开始