3免疫识别20141217详解.ppt

Damage-associated molecular patterns Review Damage-associated molecular patterns?(DAMPs), also known as alarmins, are molecules released by stressed cells undergoing necrosis that act as endogenous danger signals to promote and exacerbate the inflammatory response. The best known DAMPs are high mobility group box-1 (HMGB1),?S100A8?(MRP8, calgranulin A) and?S100A9?(MRP14, calgranulin B), and Serum amyloid A (SAA).?Increased serum levels of these DAMPs have been associated with?many inflammatory diseases, including sepsis, arthritis, atherosclerosis, lupus, Crohn’s disease and cancer. Therapeut