细胞信号转导II.ppt

Janus, Roman two faced God of Gate Question STAT is a big family. Could you design an approach to identify which STAT is essential for the maturation of red blood cells? Smads family R-Smads (receptor regulated Smads): Smad2 and Smad3, etc. Co-Smads (common Samds): Smad4 I-Smads (Inhibitory Smads): Smad6 and Smad7. TGF? pathway in physiology and pathology TNF-alpha inhibitors available by prescription Alzheimers disease Alzheimers disease is a neurodegenerative disorder characterized by dementia and progressive brain wasting. Wnt pathway and diseases NO pathway in physiology and pathology Cardiovascular diseases Neurological diseases: Brain ischemia and chronic degenerative diseases of the nervous system Erectile dysfunction (impotence): Sildenafil, popularly known by the trade name Viagra, stimulates erections primarily by enhancing signaling through the nitric oxide pathway in the penis. The Nobel Prize in Physiology or Medicine 1998 III. The network of cell signaling III. The regulation of cell signaling Questions: We currently know TGF? receptors have three different types. Could you design a simple strategy to identify if you have known TGF? ligand and positive responsible cells receptors. Are you sure that TGF? receptors only have three receptor? Why? How do you design a strategy to treat Alzheimers disease based on your knowledge of Notch signaling pathway? How do you design a strategy to treat cancer based on your knowledge of Wnt and hedgehog pathways? Notch/Delta signaling pathway TACE: TNFαconverting enzyme (αsecretase) ICN: intracellular domain of Notch CSL: CBF1/Suppressor of hairless/Lag-1, a co-repressor. ICN (γ Secretase) CSL Lodish et al., ed, Molecular Cell Biology 5th, 2004. Artist charts his slide into dementia, Galerie Beckel Odille Boicos, Paris.Six self-portraits by artist William Utermohlen chronicle his experience with Alzheimers disease. Utermohlen was diagnosed at the age of 60. The first in this series (top left) was painted i